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Fast and slow myosin in developing muscle fibres

Nature volume 274, pages 25–29 (1978)Cite this article

Abstract

Slow and fast isoenzymes of myosin coexist in all the fibres of a fast-twitch mammalian muscle during early development. They later become segregated into different populations of fibres. Slow myosin is most abundant when the speed of contraction of the muscle is slow and the fibres are multiply innervated; its synthesis in the majority of the fibres seems to be ‘switched off’ when the speed of contraction increases and the fibres become innervated by single motoneurones.

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Authors and Affiliations

  1. Laboratory of Electron Microscopy, Wellesley College, Wellesley, Massachusetts, 02181

    Geraldine F. Gauthier & Ann W. Hobbs

  2. The Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, 02154

    Susan Lowey

Authors
  1. Geraldine F. Gauthier
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  2. Susan Lowey
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  3. Ann W. Hobbs
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Gauthier, G., Lowey, S. & Hobbs, A. Fast and slow myosin in developing muscle fibres. Nature 274, 25–29 (1978). https://doi.org/10.1038/274025a0

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