Abstract
THE immune response to cytomegalovirus (CMV) infection is poorly understood, but it is believed that the cellular immune system has a critical role. It is a major cause of morbidity and mortality in homograft recipients1,2, leukaemic individuals3,4 and others receiving immunosuppressive drug therapy5. In these patients, high levels of serum antibody often fail to eradicate chronic infection6. Infection of mice with murine cytomegalovirus (MCMV)7 has provided additional evidence of the importance of T-lymphocyte function in the immune response to CMV: nude mice8, and mice treated with anti-thymocyte serum9 or undergoing graft-versus-host reaction10 all succumb to much lower infecting doses of virus than do normal mice. It has been shown that purified human CMV can induce proliferation of lymphocytes from immune individuals11, but T-cell specific responses to CMV infection have not yet been demonstrated. Cytotoxic T-lymphocyte responses have been described for several viral infections12–17. We report here a virus-specific cytotoxic T-lymphocyte (CTL) response in MCMV infection.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hedley-Whyte, E. T. & Craighead, J. E. New Engl. J. Med. 272, 473–475 (1965).
Simmons, R. L. et al. Ann. Surg. 180, 623–634 (1974).
Bodey, G. P., Wertlake, P. T., Douglas, G. & Levin, R. H. Ann. intern. Med. 62, 899–906 (1965).
Dyment, P. G., Orlando, S. J., Isaacs, H., Jr & Wright, H. T., Jr J. Pediat. 72, 533–536 (1968).
Abdallah, P. S., Mark, J. B. D. & Merigan, T. C. Am. J. Med. 61, 326–331 (1976).
Stern, H., Elek, S. D., Booth, J. C. & Fleck, D. G. Lancet ii, 443–448 (1969).
Plummer, G. Prog. med. Virol. 15, 92–125 (1973).
Starr, S. E. & Allison, A. C. Infect. Immun. 17, 453–462 (1977).
Brody, A. R. & Craighead, J. E. J. infect. Dis. 129, 677–689 (1974).
Dowling, J. N., Wu, B. C., Armstrong, J. A. & Ho, M. J. infect. Dis. 135, 990–994 (1977).
Moller-Larsen, A., Anderson, H. K., Heron, I. & Sarov, I. Intervirology 6, 249–257 (1976).
Ennis, F. A., Martin, W. J., Verbonitz, M. W. & Butchko, G. M. Proc. natn. Acad. Sci. U.S.A. 74, 3006–3010 (1977).
Kim, K. S., Sajienza, V. & Carp, R. I. Infect. Immun. 10, 672–674 (1974).
Roos, D. & Loss, J. A. Biochim. biophys. Acta 222, 565–582 (1970).
Julius, M., Simpson, E. & Herzenbeig, L. A. Eur. J. Immun. 3, 645–648 (1973).
Murasko, D. M. & Lausch, R. N. Int. J. Cancer 16, 24–32 (1975).
Ennis, F. A. Infect. Immun. 7, 898–904 (1973).
Klein, J. Biology of the Mouse Histocompatibility-2 Complex (Springer, New York, 1975).
Yap, K. L. & Ada, G. L. Immunology 32, 151–159 (1977).
Hutt, L. M., Huang, Y. T., Dascomb, H. E. & Pagano, J. S. J. Immun. 115, 243–248 (1975).
Pfizenmaier, K., Starzinski-Powitz, A., Rollinghoff, M., Falke, D. & Wagner, H. Nature 265, 630–632 (1977).
Lausch, R. N., Jones, C., Christie, D., Hay, K. A. & Rapp, F. J. Immunology 114, 459–465.
Thong, Y. H. et al. Infect. Immun. 13, 643–645 (1976).
Diamond, R. D., Keller, R., Lee, G. & Finkel, D. Proc. Soc. exp. Biol. Med. 154, 259–263 (1977).
Murasko, D. M. & Lausch, R. N. Int. J. Cancer 14, 451–460 (1970).
Rola-Pleszczynski, M. et al. J. infect. Dis. 135, 386–391 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
QUINNAN, G., MANISCHEWITZ, J. & ENNIS, F. Cytotoxic T lymphocyte response to murine cytomegalovirus infection. Nature 273, 541–543 (1978). https://doi.org/10.1038/273541a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/273541a0
This article is cited by
-
Lactoferrin-mediated protection of the host from murine cytomegalovirus infection by a T-cell-dependent augmentation of natural killer cell activity
Archives of Virology (1996)
-
Cytomegalovirus and latency: an overview
Virchows Archiv B Cell Pathology Including Molecular Pathology (1993)
-
Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection
Nature (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.