Abstract
INTENSIVE studies in a variety of animal species have led to the recognition that cell interaction is important for the generation of an immune response1. The participation of macrophages and of T and B lymphocytes in the process of antibody formation has been demonstrated both in vivo and in vitro2,3. More recently, attention has been focused on the mechanism(s) regulating the development and expression of immune reactivity, leading to the discovery in a number of animal species of subpopulations of T cells with different functions, such as helper cells (Th) and suppressor cells (Ts) (refs 4-6). Dosch and Gelfand7 recently reported that the induction of plaque forming cells (PFC) in human tonsillar or blood lymphocytes is abolished if a (relatively) high antigen dose is used and we have confirmed this finding using the antigens sheep red blood cells (SRBC), ovalbumin (OA) and haemocyanin (Hc)8. We have extended these studies and report here the in vitro generation of antigen-specific Ts cells in man.
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References
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UYTDEHAAG, F., HEYNEN, C. & BALLIEUX, R. Induction of antigen-specific human suppressor T lymphocytes in vitro. Nature 271, 556–557 (1978). https://doi.org/10.1038/271556a0
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DOI: https://doi.org/10.1038/271556a0
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