Abstract
β-NORADRENERGIC receptor detection with radiolabelled catecholamines has been hampered by binding of catecholamines to other sites1,2. Lefkowitz and Williams3 described binding of a synthetic catecholamine 3H-hydroxybenzylisoprenaline to β-noradrenergic receptors on frog red blood cell membranes. Using procedures to prevent metabolism and nonspecific binding, we identified binding of 3H-adrenaline to α-noradrenergic receptor sites in brain membranes4,5. We report here the labelling of β-noradrenergic receptors in membranes of the calf cerebellum with 3H-adrenaline.
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U'PRICHARD, D., SNYDER, S. Differential labelling of α and β-noradrenergic receptors in calf cerebellum membranes with 3H-adrenaline. Nature 270, 261–263 (1977). https://doi.org/10.1038/270261a0
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DOI: https://doi.org/10.1038/270261a0
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