Abstract
IN mice thymus-derived lymphocytes express θ-antigen specificities in two allelic forms, Th–1.1 (formerly called θAKR) and Th–1.2 (θ-C3H), which are distributed reciprocally among the various mouse strains1,2. Rats have also been tested for the occurrence of antigens of the Th–1 system, but so far all strains have been positive with anti-Th–1.1 only3,4. Rats also differ from mice in the concentration of Th–1.1 carrying cells, which, in rats, is much higher in the bone marrow and lower in the peripheral lymphoid organs5. The stage at which haemopoietic stem cells differentiate towards thymocytes carrying the θ alloantigen is still ill-defined. We present here evidence that in rats Th–1.1 is already expressed on haemopoietic stem cells while murine haemopoietic stem cells have not yet developed this θ alloantigen.
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THIERFELDER, S. Haemopoietic stem cells of rats but not of mice express Th–1.1 alloantigen. Nature 269, 691–693 (1977). https://doi.org/10.1038/269691a0
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DOI: https://doi.org/10.1038/269691a0
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