Abstract
WHEN Drosophila imaginal disk tissue is cultured in vivo1, the proliferating cells can adopt new fates within the limits of a single disk (‘pattern regulation’2,3) or may even produce structures normally derived from a different disk (‘transdetermination’4). Much of the pattern regulation occurring in imaginal disk fragments may be controlled by interactions between cells that come together during wound healing3,5. I report here further studies on the role of cell interactions in pattern regulation and transdetermination, by means of dissociation and reaggregation of specific disk parts. The data confirm the importance of cell interactions for pattern regulation, and suggest that interactions between cells with large positional disparities may also be crucial for the stimulation of transdetermination.
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STRUB, S. Pattern regulation and transdetermination in Drosophila imaginal leg disk reaggregates. Nature 269, 688–691 (1977). https://doi.org/10.1038/269688a0
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DOI: https://doi.org/10.1038/269688a0
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