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Effects of a nonapeptide FTS on lymphocyte differentiations in vitro

Nature volume 269, pages 597–598 (1977)Cite this article

Abstract

BACH et al.1,2 have reported the amino acid sequence of a putative thymic hormone isolated from pig serum3, a nonapeptide called FTS (facteur thymique serique). Natural and synthetic FTS showed high activity in the rosette test used as a bioassay1,2. Bioassays for thymic hormones4, however, can be spuriously triggered by many substances of non-thymic origin5, a finding probably related to mediation by a cyclic AMP second signal6. Early steps in B-cell differentiation are also mediated by cyclic AMP (refs 6–9) and comparison of induction of T cells and B cells from committed precursor cells in vitro (the dual induction assay) enables a distinction to be made between selective and non-selective inducing agents7,8. This is exemplified by induction studies in the mouse with thymopoietin10,11 and ubiquitin7,12,13. Bovine thymopoietin selectively induces T-cell differentiation and actually inhibits B-cell differentiation9. By contrast, ubiquitin is non-selective, inducing both T- and B-cell differentiation7. Ubiquitin at high concentrations does not induce differentiation whereas these high concentrations do not impair induction by thymopoietin or other agents8,14. Another feature of induction by ubiquitin is its inhibition by the β-adrenoceptor-blocking drug propranolol, which is without effect on induction by thymopoietin7. We have evaluated synthetic FTS in the dual induction system in the chicken to determine whether it showed inductive selectivity appropriate to a thymic hormone, and have found that it induced non-selective differentiation of both T cells and B cells and closely resembled ubiquitin in its activity.

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References

  1. Bach, J. F., Dardenne, M., Pleau, J. M. & Rosa, J. C.r. hèbd. Acad. Sci. Paris. 283, 1605–1607 (1977).

    Google Scholar 

  2. Bach, J. F., Dardenne, M. & Pleau, J. M. Nature 266, 55–58 (1977).

    Article  ADS  CAS  Google Scholar 

  3. Bach, J. F., Dardenne, M., Pleau, J. M. & Bach, M. A. Ann. N.Y. Acad. Sci 249, 186–210 (1975).

    Article  ADS  CAS  Google Scholar 

  4. Komuro, K. & Boyse, E. A. Lancet i, 740–743 (1973).

    Article  Google Scholar 

  5. Scheid, M. P. et al. J. exp. Med. 138, 1027–1032 (1973).

    Article  CAS  Google Scholar 

  6. Scheid, M. P., Goldstein, G., Hammerling, U. & Boyse, E. A. Ann. N.Y. Acad. Sci. 249, 531–540 (1975).

    Article  ADS  CAS  Google Scholar 

  7. Goldstein, G. et al. Proc. natn. Acad. Sci. U.S.A. 72, 11–15 (1975).

    Article  ADS  CAS  Google Scholar 

  8. Brand, A., Gilmour, D. G. & Goldstein, G. Science 193, 319–321 (1976).

    Article  ADS  CAS  Google Scholar 

  9. Hammerling, U. et al. Eur. J. Immun. 6, 868–872 (1976).

    Article  Google Scholar 

  10. Schlesinger, D. H. & Goldstein, G. Cell 5, 361–365 (1975).

    Article  CAS  Google Scholar 

  11. Schlesinger, D. H., Goldstein, G., Scheid, M. P. & Boyse, E. A. Cell 5, 367–370 (1975).

    Article  CAS  Google Scholar 

  12. Schlesinger, D. H. & Goldstein, G. Nature 255, 423–424 (1975).

    Article  ADS  CAS  Google Scholar 

  13. Schlesinger, D. H., Goldstein, G., Scheid, M., Boyse, E. A. & Tregear, G. Fedn Proc. 34, 551 (1975).

    Google Scholar 

  14. Twomey, J. J., Goldstein, G., Lewis, V. M., Bealmear, P. M. & Good, R. A. Proc. natn. Acad. Sci. U.S.A. 74, 2541–2546 (1977).

    Article  ADS  CAS  Google Scholar 

  15. Barker, W. C. & Dayhoff, M. O. in Atlas of Protein Sequence and Structure (ed. Dayhoff, M. O.) 108–109 (National Biomedical Research Foundation, Washington, DC, 1972).

    Google Scholar 

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Author information

Author notes

  1. GIDEON GOLDSTEIN

    Present address: Ortho Pharmaceutical Corporation, Raritan, New Jersey, 08869

Authors and Affiliations

  1. Department of Microbiology, New York University Medical Center, New York, New York, 10016

    ANN BRAND & DOUGLAS G. GILMOUR

  2. Memorial Sloan-Kettering Cancer Center, New York, New York, 10021

    GIDEON GOLDSTEIN

Authors
  1. ANN BRAND
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  2. DOUGLAS G. GILMOUR
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  3. GIDEON GOLDSTEIN
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BRAND, A., GILMOUR, D. & GOLDSTEIN, G. Effects of a nonapeptide FTS on lymphocyte differentiations in vitro. Nature 269, 597–598 (1977). https://doi.org/10.1038/269597a0

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