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Protein–DNA and protein–hormone interactions in prealbumin: a model of the thyroid hormone nuclear receptor?

Nature volume 268, pages 115–120 (1977)Cite this article

Abstract

High resolution X-ray analysis of the hormone-binding protein prealbumin has shown that it has a structural complementarity to double-helical DNA. The proposed binding site is composed of two symmetry-related β-sheets containing a pair of helically disposed arms, which can interact with the bases in the wide groove of DNA. A palindromic target sequence is indicated by the symmetry of the protein. The two identical thyroid hormone binding sites on prealbumin are located in a channel that runs completely through the molecule. These two structural features suggest prealbumin as a model for the thyroid hormone nuclear receptor, providing a number of detailed predictions of its properties.

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Authors and Affiliations

  1. Laboratory of Molecular Biophysics, Department of Zoology, South Parks Road, Oxford, UK

    C. C. F. Blake & S. J. Oatley

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  1. C. C. F. Blake
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  2. S. J. Oatley
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Blake, C., Oatley, S. Protein–DNA and protein–hormone interactions in prealbumin: a model of the thyroid hormone nuclear receptor?. Nature 268, 115–120 (1977). https://doi.org/10.1038/268115a0

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