Abstract
THE central role of cyclic 3′,5′-adenosine monophosphate in intestinal secretion has been emphasised recently1,2. Electrolyte absorption is converted to secretion3,4 and mucosal conductance is reduced5,6 by increases in epithelial cyclic AMP concentrations and this is held to mediate the profound secretion provoked by cholera and other forms of infective ‘toxigenic’ diarrhoea7. The mechanisms of the intestinal response to cyclic AMP are incompletely understood and we therefore examined this response in human intestinal mucosa. We report here that changes in mucosal permeability are largely determined by the state of the lateral intercellular spaces. When these spaces are open, permeability is increased by cyclic AMP and when they are closed, permeability is decreased. These changes in permeability have a profound effect on the ion transport responses to cyclic AMP.
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CORBETT, C., ISAACS, P., HAWKER, P. et al. Theophylline-induced changes in ion transport and conductance in human small intestinal mucosa. Nature 267, 714–717 (1977). https://doi.org/10.1038/267714a0
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DOI: https://doi.org/10.1038/267714a0
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