Abstract
LIKE other minus-strand RNA viruses1–5, influenza virus seemed to contain protein kinase as well as viral transcriptase in, or in association with, nucleocapsid structure6. The kinase phosphorylates NP-protein constituting the nucleocapsid, but none of the other virion proteins in in vitro reaction6. Since the influenza virus RNA serves as a template for transcription in the form of nucleocapsid in which the viral RNA is tightly packed in helical array of NP-protein7–9, it is tempting to implicate the NP-protein phosphorylation in the control of viral transcription. We report here that the phosphorylation of NP-protein stimulates viral transcription, and that some conformational changes in the nucleocapsid may be involved in the stimulation of transcription.
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KAMATA, T., WATANABE, Y. Role for nucleocapsid protein phosphorylation in the transcription of influenza virus genome. Nature 267, 460–462 (1977). https://doi.org/10.1038/267460a0
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DOI: https://doi.org/10.1038/267460a0
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