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Cross-tolerance between morphine and cholinergic blocking agents microinjected into anterior amygdala

Nature volume 267, pages 452–453 (1977)Cite this article

Abstract

WE have previously demonstrated tolerance to repeated applications of opiates microinjected directly into the amygdaloid region of the brain1. Since morphine has been shown to inhibit the release of acetylcholine at some brain sites2,3, as well as in the isolated guinea pig ileum4,5, we compared the effect of morphine on amygdala bioelectric patterns with the effects of hemicholinium and scopolamine—two drugs that interfere with cholinergic synaptic activity in different ways. Tolerance that is produced with repeated administration of morphine is associated with cross-tolerance to hemicholinium and scopolamine.

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  1. Behavioral Sciences Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland, 20014

    HERMAN TEITELBAUM

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  1. HERMAN TEITELBAUM
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TEITELBAUM, H. Cross-tolerance between morphine and cholinergic blocking agents microinjected into anterior amygdala. Nature 267, 452–453 (1977). https://doi.org/10.1038/267452a0

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