Abstract
5-HYDROXYTRYPTAMINE (5-HT) is known to be a powerful activator of the sensory nerve endings1 and a potent stimulant of sympathetic ganglia2–4. Very little is known, however, about the nature of 5-HT receptors and the ionic basis of the 5-HT-induced membrane potential changes5,6. Here I report the existence of 5-HT receptors on the soma of afferent neurones of the nodose ganglion of the vagus and the ionic requirements of the response elicited by activation of these receptors.
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References
Paintal, A. S. Pharmac. Rev. 16, 341–380 (1964).
Haefely, W. in Handbook of Experimental Pharmacology XXXIII (eds Blashko, H. & Muscholl, E.) 661–725 (Springer, Berlin, Heidelberg & New York, 1972).
Haefely, W. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 281, 145–165 (1974).
North, R. A. & Wallis, D. I. Br. J. Pharmac. 59, 505p (1977).
Watanabe, S. & Koketsu, K. Experimenta 29, 1371–1372 (1973).
Wallis, D. I. & Woodward, B. Br. J. Pharmac. 55, 199–212 (1975).
Jaffe, R. A. & Sampson, S. R. J. Neurophysiol. 39, 802–815 (1976).
Jordan, L. M., Frederickson, R. C. A., Phillis, J. W. & Lake, N. Brain Res. 40, 552–558 (1972).
Deshenes, M., Feltz, P. & Lamour, Y. Brain Res. 118, 486–493 (1976).
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HIGASHI, H. 5-Hydroxytryptamine receptors on visceral primary afferent neurones in the nodose ganglion of the rabbit. Nature 267, 448–450 (1977). https://doi.org/10.1038/267448a0
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DOI: https://doi.org/10.1038/267448a0
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