Abstract
BY culturing normal rodent lymphocytes together with foreign stimulator cells, lymphocytes are generated, which can destroy target cells bearing transplantation antigens identical with the ones on the stimulator cells1–3. When these stimulated lymphocytes are cultured further in the absence of the primary cellular antigen, they will revert, morphologically, to small lymphocytes4–6. These primed ‘secondary’ (2°) lymphocytes7 are functionally oligoclonal memory cells which can be reactivated only by stimulator cells, which resemble, antigenically, the ones that caused the primary stimulation. We have studied the occurrence of a parallel phenomenon with self, rather than foreign, tissue and have established that normal rat lymph node cells can be autosensitised in vitro against dissociated testis cells from the same donor animal8. I report here that the self responsive activated lymphocytes can also be made to revert back to quiescent small secondary lymphocytes and that immunological memory can be induced in vitro against autoantigens.
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WEKERLE, H. In vitro induction of immunological memory against testicular autoantigens. Nature 267, 357–358 (1977). https://doi.org/10.1038/267357a0
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DOI: https://doi.org/10.1038/267357a0
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