Abstract
THE mixed leukocyte culture (MLC) reaction is largely a measure of specific responsiveness of thymus-derived lymphocytes to foreign allogeneic and xenogeneic major histocompatibility complex (MHC) controlled LD antigens1. In view of the remarkable primary structure homologies of MHC-controlled SD antigens between humans and mice2, we have investigated whether MHC LD antigens have also been conserved in evolution by studying the extent of LD sharing between different species. Using the primed lymphocyte typing (PLT) test, we have found extensive sharing of LD antigens between humans and monkeys, and less, but still significant, sharing between humans and dogs and humans and cattle. In no case was there evidence that mouse LD antigens were shared with those of humans.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Peck, A. B., Alter, B. J. & Lindahl, K. F. Transpl. Rev. 29, 189–221 (1976).
Silver, J. & Hood, L. Contemporary Top. molec. Immun. (in the press).
Bach, F. H. et al. Scand. J. Immun. (in the press).
Lindahl, K. F. & Bach, F. H. J. exp. Med. 144, 305–318 (1976).
Sondel, P. M., Sheehy, M. J., Bach, M. L. & Bach, F. H. Histocompatibility Testing 1975 (ed. Kissmeyer-Nielsen, F.) 581–583 (Munksgaard, Copenhagen, 1975).
Wilson, D. B., Blyth, J. L. & Nowell, P. C. J. exp. Med. 128, 1157–1181 (1968).
Bach, F. H., Graupner, K., Day, E. & Kostermann, H. Proc. natn. Acad. Sci. U.S.A. 62, 377–384 (1969).
Binz, H. & Wigzell, H. J. exp. Med. 142, 1218–1230 (1975).
Binz, H. & Wigzell, H. J. exp. Med. 142, 1231–1240 (1975).
Zoschke, D. C. & Bach, F. H. Science 172, 1350–1352 (1971).
Hirschberg, H., Rankin, B. & Thorsby, E. Cell. Immun. 10, 458–466 (1974).
Widmer, M. B. & Bach, F. H. J. exp. Med. 135, 1204–1208 (1972).
Asantila, T., Vahala, J. & Toivanen, P. Immunogenetics 1, 272–290 (1974).
Jerne, N. K. Eur. J. Immun. 1, 1–9 (1971).
Hirschberg, H., Rankin, B. & Thorsby, E. Transplantation 17, 593–599 (1974).
Bach, F. H., Bach, M. L., Sondel, P. M. & Sundharadas, G. Transpl. Rev. 12, 30–56 (1972).
Ford, W. L., Simmonds, S. J. & Atkins, P. C. J. exp. Med. 141, 681–696 (1975).
Wilson, D. B. & Nowell, P. C. J. exp. Med. 131, 391–407 (1970).
Shonnard, J. W., Cramer, D. V., Polosky, P. E., Kunz, H. W. & Gill, T. J., III Immunogenetics (in the press).
Klein, J. in Biology of the Mouse Histocompatibility-2 Complex, 296–300 (Springer, Berlin, 1975).
Bach, F. H. & van Rood, J. J. New Eng. J. Med. 295, 806–813, 872–878, 927–936 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MARTINIS, J., BACH, F. Human LD antigens are present on xenogeneic cells. Nature 266, 540–542 (1977). https://doi.org/10.1038/266540a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/266540a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.