Abstract
SEVERAL kinds of cells involved in immunity can bind antibody or immune complexes through surface receptors which interact with the Fc portion of IgG (Fc receptors). The expression of Fc receptors on mononuclear phagocytes (monocytes/macrophages) can undergo changes in response to various stimuli both in vitro1 and in vivo1–3 and such changes may play a regulatory role in the induction of an immune response and in immunological effector mechanisms. Here I show that the expression of Fc receptors on circulating human monocytes is substantially increased in individuals with solid malignant tumours. This change seems not to be a normal characteristic of infectious or inflammatory diseases of a non-malignant nature.
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RHODES, J. Altered expression of human monocyte Fc receptors in malignant disease. Nature 265, 253–255 (1977). https://doi.org/10.1038/265253a0
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DOI: https://doi.org/10.1038/265253a0
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