Abstract
THE cerebellum has an important function in the coordination of movement and in the regulation of posture. Neurophysiological studies have established that Purkinje cell activity is stimulated by mossy and climbing fibres, which are two distinct afferent excitatory pathways to the cerebellum1. Biochemically, an increase or a decrease in the activity of mossy and climbing fibres together with either an activation or inhibition of gamma aminobutyric acid (GABA) synapses of Golgi, basket and Purkinje cells results in changes of the cyclic 3′,5′-guanosine monophosphate (cyclic GMP) content of the cerebellar cortex2–5. Therefore, by measuring cyclic GMP in the cerebellar cortex one might infer whether drugs which influence the planning of motor activity and modify operant behaviour also change the activity of the excitatory cerebellar afferents or the function of the inhibitory intracerebellar neurones which presumably employs GABA as transmitter.
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BIGGIO, G., GUIDOTTI, A. Regulation of cyclic GMP in cerebellum by a striatal dopaminergic mechanism. Nature 265, 240–242 (1977). https://doi.org/10.1038/265240a0
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DOI: https://doi.org/10.1038/265240a0
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