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Re-analysis of radiation-induced specific locus mutations in the mouse

Nature volume 264, pages 715–719 (1976)Cite this article

Abstract

A re-analysis of published data on mouse mutation rates induced by X and gamma rays suggests that the kinetics of induction can be analysed by fitting the data to a parabolic curve. We interpret this to mean that a substantial proportion of the induced mutations results from gross chromosomal changes such as deletions, some of which are one-track and some of which are two-track. This analysis is based on the assumption that the shape of the dose curve, which in the female is concave upward, reflects the manner in which the mutations are induced rather than representing a one-track (linear) curve whose shape has been modified by differential repair.

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References

  1. Russell, W. L., Cold Spring Harbor Symp. quant. Biol. 16, 327–336 (1951).

    Article  CAS  PubMed  Google Scholar 

  2. Russell, W. L., Russell, L. B., and Kelly, E. M., Science 128, 1546–1550 (1958).

    Article  CAS  ADS  PubMed  Google Scholar 

  3. Russell, W. L., Proc. natn. Acad. Sci. U.S.A., 48, 1724–1727 (1962).

    Article  CAS  ADS  Google Scholar 

  4. Russell, W. L., in Repair from Genetic Radiation Damage, (edit. by Sobels F. H.) 205–217 (Pergamon, Oxford, 1963).

    Google Scholar 

  5. Russell, W. L., Suppl. Jap. J. Genet., 40, 128–140 (1965).

    CAS  Google Scholar 

  6. Russell, W. L., Nucleonics, 23, 53–56 (1965).

    Google Scholar 

  7. Russell, W. L., Proc. natn. Acad. Sci. U.S.A., 54, 1552–1557 (1965).

    Article  CAS  ADS  Google Scholar 

  8. Russell, W. L., in Recovery and Repair Mechanisms in Radiobiology: Brookhaven Symp. Biol., 20 179–189 (1968).

    Google Scholar 

  9. Russell, W., L., Pediatrics, 41, 223–230 (1968).

    Google Scholar 

  10. Russell, W., I., Peaceful Uses of Atomic Energy: 4th 1971, vol. 13, 487–500 (1972).

    Google Scholar 

  11. Carter, T. C., Br. J. Radial. 31, 407–411 (1958).

    Article  CAS  ADS  Google Scholar 

  12. Phillips, R. J. S., Br. J. Radiol., 34, 261–264 (1961).

    Article  CAS  PubMed  Google Scholar 

  13. Lyon, M. F., Phillips, R. J. S., and Bailey, H. J., Mutation Res., 15, 185–190 (1972).

    Article  CAS  PubMed  Google Scholar 

  14. Lyon, M. F., and Phillips, R. J. S., Mutation Res., 30, 375–382 (1975).

    Article  CAS  PubMed  Google Scholar 

  15. Russell, W. L., Russell, L. B., and Kelly, E. M., Int. J. Radial. Biol. (Suppl.), 311–320 (1960).

  16. Lyon, M. F., and Morris, T., Mutation Res., 8, 191–198 (1969).

    Article  CAS  PubMed  Google Scholar 

  17. Cattanach, B. M., and Moseley, H., Mutation Res., 25, 63–72 (1974).

    Article  CAS  PubMed  Google Scholar 

  18. Searle, A. G., in Advances in Radiation Biology, (edit by Lett, J. T., Adler, H., and Zelle, M.) vol. 4, 131–207 (Academic, New York, 1974).

    Google Scholar 

  19. United Nations Scientific Committee on the Effects of Atomic Radiation. Ionizing Radiation: Levels and Effects, vol. 2, Effects (United Nations, New York, 1972).

  20. BEIR Report (National Academy of Sciences–National Research Council, Washington, DC, 1972).

  21. Wolff, S., in A. Rev. Genet., 1, 221–244 (1971).

    Google Scholar 

  22. Russell, L. B., Mutation Res., 11, 107–123 (1971).

    Article  CAS  PubMed  Google Scholar 

  23. Russell, W. L., Am. Nat., 90, Suppl. (69–80 1956).

    Article  Google Scholar 

  24. Luria, S. E., and Delbruck, M., Genetics, 28, 491–511 (1943).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Pedersen, I., in Oogenesis, (edit. by Biggers, J. D., and Schuetz, A. W.), 361–376 (University Park Press, Baltimore, 1972).

    Google Scholar 

  26. Bronson, F. H., Dagg, C. P., and Snell, G. D., in Biology of the Laboratory Mouse, (edit. by Green, E. L.) (McGraw-Hill, New York, 1966).

    Google Scholar 

  27. Oakberg, E. F., and Tyrrell, P. D., Biology of Reproduction, 12, 477–482 (1975).

    Article  CAS  PubMed  Google Scholar 

  28. Russell, L. B., and Russell, W. L., Cold Spring Harb. Symp. quant. Biol., 19, 50–59 (1954).

    Article  CAS  PubMed  Google Scholar 

  29. Mandl, A. M., Proc. R. Soc., B 150, 53–71 (1959).

    CAS  ADS  Google Scholar 

  30. Oakberg, E. F., and Clark, E., Effects of Ionising Radiation in the Reproductive System, 11–24 (Pergamon, New York, 1963).

    Google Scholar 

  31. Russell, W. L., Russell, L. B., Gower, J. S., and Maddux, S. C., Proc. natn. Acad. Sci. U.S.A., 44, 901–905 (1958).

    Article  CAS  ADS  Google Scholar 

  32. Mandl, A. M., Biol. Rev. Cambridge Phil. Soc., 39, 288–371 (1964).

    Article  CAS  Google Scholar 

  33. Baker, T. G., Mutation Res., 11, 9–22 (1971).

    Article  CAS  ADS  PubMed  Google Scholar 

  34. Searle, A. G., and Beechey, C. V., Mutation Res., 24, 171–186 (1971).

    Article  Google Scholar 

  35. Lyon, M. F., Papworth, D. G., and Phillips, R. J. S., Nature new Biol., 238, 101–104 (1972).

    Article  CAS  PubMed  Google Scholar 

  36. Wolff, S., Mutation Res., 15, 435–444 (1972).

    Article  CAS  PubMed  Google Scholar 

  37. Wolff, S., and Luippold, H. E., Science, 122, 231–232 (1955).

    Article  CAS  ADS  PubMed  Google Scholar 

  38. Schmid, E., and Bauchinger, M., Mutation Res., 27, 111–117 (1975).

    Article  CAS  PubMed  Google Scholar 

  39. Kellerer, A. M., and Rossi, H. H., Current Topics in Radiation Research Quart., 8, 85–158 (1972).

    CAS  Google Scholar 

  40. Lea, D. E., Actions of Radiations on Living Cells (Cambridge University, Cambridge, 1946).

    Google Scholar 

  41. Wolff, S., Atwood, K. C., Randolph, M. L., and Luippold, H. E., J. biophys. biochem. Cytol., 4, 365–372 (1958).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Abrahamson, S., in Biological and Environmental Effects of Low Level Radiation, 3–8 (IAEA, Vienna, 1976).

    Google Scholar 

  43. Searle, A. G., and Phillips, R. J. S., Mutation Res., 11, 97–105 (1971).

    Article  CAS  PubMed  Google Scholar 

  44. Crow, E. L., and Gardner, R. S., Biometrika, 46, 441–453 (1959).

    Article  MathSciNet  Google Scholar 

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Authors and Affiliations

  1. Departments of Genetics and Zoology, University of Wisconsin, Madison, Wisconsin, 53706

    Seymour Abrahamson

  2. Laboratory of Radiobiology and Department of Anatomy, University of California, San Francisco, 94143

    Sheldon Wolff

Authors
  1. Seymour Abrahamson
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  2. Sheldon Wolff
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Abrahamson, S., Wolff, S. Re-analysis of radiation-induced specific locus mutations in the mouse. Nature 264, 715–719 (1976). https://doi.org/10.1038/264715a0

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