Abstract
UNTIL quite recently, the possibility that naturally occurring peptides, with a few exceptions, such as substance P, might function to modify the excitability of neurones in the central nervous system (CNS) was considered rather remote. There is now increasing evidence to suggest that peptides have a greater range of actions and are more widely distributed than previously thought1–6. In a search for physiologically active peptides in the CNS we have isolated a tripeptide from the dorsal columns of cat spinal cord, which has been partially characterised as His–(Gly, Lys). We have synthesised the two possible forms and tested their activity by iontophoretic application to single neurones in the spinal cord, the medial medulla oblongata and the dorsal column nuclei.
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LOTE, C., GENT, J., WOLSTENCROFT, J. et al. An inhibitory tripeptide from cat spinal cord. Nature 264, 188–189 (1976). https://doi.org/10.1038/264188a0
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DOI: https://doi.org/10.1038/264188a0
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