Abstract
TWO principal mechanisms seem to be responsible for the bone destruction associated with skeletal metastases. The earlier and quantitatively most important mechanism seems to be mediated by osteoclasts stimulated by material produced by the tumour1. We now report evidence that this material is, or contains, prostaglandin. There are precedents for such a conclusion. Various tumours contain prostaglandins2, which resorb bone in organ culture3. Prostaglandin formation may explain the growth of dental cysts in the human jaw4, and prostaglandin synthetase inhibitors reduce tumour-induced osteolysis5 and hypercalcaemia6.
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GALASKO, C., BENNETT, A. Relationship of bone destruction in skeletal metastases to osteoclast activation and prostaglandins. Nature 263, 508–510 (1976). https://doi.org/10.1038/263508a0
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DOI: https://doi.org/10.1038/263508a0
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