Abstract
FOR several years evidence has been accumulating to indicate that the erythrocytes of individuals with sickle cell anaemia not only contain an abnormal haemoglobin but also exhibit several altered membrane characteristics. These include increased cation transport1, possible alterations in phospholipid arrangement2, and increased membrane rigidity3. The protein and glycoprotein content of membranes from erythrocytes of individuals with sickle cell anaemia does not seem to differ from that of normal erythrocyte membranes4. Many of the altered membrane characteristics appear to be a function of altered erythrocyte membrane structure due to membrane–haemoglobin interactions5, however, whether or not other membranous protein–protein interactions are altered is not well documented.
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HOSEY, M., TAO, M. Altered erythrocyte membrane phosphorylation in sickle cell disease. Nature 263, 424–425 (1976). https://doi.org/10.1038/263424a0
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DOI: https://doi.org/10.1038/263424a0
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