Abstract
CHRONIC intoxication with ethanol has been shown to result in tolerance to and physical dependence on this drug1,2. In general, the development of tolerance and physical dependence during intake of addictive compounds have been looked on as inexorably linked phenomena produced by a common biochemical3 or physiological4 mechanism. This was supported by the studies of Way et al.5 who demonstrated a simultaneous development and disappearance of tolerance and physical dependence after morphine pellet implantation in mice. We were interested in the possible application of the same theoretical framework to the development of tolerance to and physical dependence on ethanol. Previous work6,7 demonstrating changes in noradrenergic systems in brain after chronic treatment led us to study the effect of 6-hydroxydopamine (6-OHDA) pretreatment on the development of tolerance to and physical dependence on ethanol.
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RITZMANN, R., TABAKOFF, B. Dissociation of alcohol tolerance and dependence. Nature 263, 418–420 (1976). https://doi.org/10.1038/263418a0
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DOI: https://doi.org/10.1038/263418a0
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