Abstract
Studies of the growth behaviour and hormone receptor contents of GR-mouse mammary tumours suggest that the hormone responsive tumours are mixed populations of hormone-dependent cells and autonomous cells. The hormone-dependent moiety of these tumours contains high levels of progesterone receptor and oestrogen receptor. The autonomous moiety has a low but probably significant oestrogen receptor level, and is practically devoid of progesterone receptor. Androgen receptor levels in both moieties are low. Endocrine ablation prevents growth of the hormone-dependent moiety of the tumours, but not of the autonomous moiety.
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Sluyser, M., Evers, S. & De Goeij, C. Sex hormone receptors in mammary tumours of GR mice. Nature 263, 386–389 (1976). https://doi.org/10.1038/263386a0
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DOI: https://doi.org/10.1038/263386a0
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