Abstract
GONADOTROPIN-RELEASING hormone (GnRH) and thyrotropin-releasing hormone (TRH) are two hypothalamic oligopeptides which regulate the secretion of gonadotropins and of thyroid-stimulating hormone (TSH), respectively, from the anterior pituitary1,2. It is generally accepted that these neurohormones are produced by nerve cells, transmitted along axons and stored in nerve endings; when released, they are transferred by way of the hypothalamo–hypophyseal portal system to the anterior pituitary3. Human brains of adults have been shown to contain GnRH and TRH activity4 but quantitative measurements of these hormones are available for brains of aborted foetuses only5. This report deals with the distribution of GnRH and TRH in the adult human brain, their possible sites of formation, routes of migration and sites of storage in the pituitary stalk.
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OKON, E., KOCH, Y. Localisation of gonadotropin-releasing and thyrotropin-releasing hormones in human brain by radioimmunoassay. Nature 263, 345–347 (1976). https://doi.org/10.1038/263345a0
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DOI: https://doi.org/10.1038/263345a0
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