Abstract
THE propensity of human IgA and IgM monoclonal proteins to complex to endogenous serum proteins, such as albumin and α1 antitrypsin (α1AT), has been previously established1–3. When complexes of IgA-albumin and IgA-α1 antitrypsin are isolated, albumin and α1AT are found on separate polymeric IgA molecules and not on monomeric IgA3. Another polypeptide chain, J chain, has also been shown to exist in polymeric IgA and IgM (refs 4 and 5) but not monomeric immunoglobulin. Furthermore, J chain is synthesised within IgA and IgM mouse plasma cells6. Therefore, it is important to determine whether albumin is complexed to immunoglobulin as a step in intracellular biosynthesis or whether it is incorporated as a post-secretory event. We report here that IgG and IgA mouse plasmacytoma cells synthesise and secrete albumin complexed to immunoglobulin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Heremans, J. F., Les Globulins Seriques du Systeme Gamma (Editions arcia, Brussels, 1960).
Mannik, M., J. Immun., 99, 899–906 (1967).
Tomasi, T. B., Jr, and Hauptman, S. P., J. Immun., 112, 2274–2277 (1974).
Halpern, M. S., and Koshland, M. E., Nature, 228, 1276–1278 (1970).
Mastecky, J., Zikan, J., and Butler, W. T., Science, 111, 1163–1165 (1971).
Parkhouse, R. M. E., Nature new Biol., 236, 9–11 (1972).
Laskov, R., and Scharff, M. D., J. exp. Med., 131, 515–541 (1970).
Laskov, R., Lanzerotti, R., and Scharff, M. D., J. molec. Biol., 56, 327–339 (1971).
Greenwood, F. C., and Hunter, W. M., Biochem. J., 89, 114–123 (1963).
McConahey, P. J., and Dixon, F. J., Int. Archs Allerg. appl. Immun., 29, 185–189 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HAUPTMAN, S., SOBCZAK, G. Origin of immunoglobulin–albumin complexes. Nature 263, 64–67 (1976). https://doi.org/10.1038/263064a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/263064a0
This article is cited by
-
C1q-bearing immune complexes detected by a monoclonal antibody to human C1q in rheumatoid arthritis sera and synovial fluids
Rheumatology International (1991)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
