Abstract
THE widespread use of large doses of oestrogenic steroids as contraceptive agents or for maintenance therapy in post-menopausal women has led to damaging effects on the cardiovascular system. Most of the reports relate to the increased thromboembolic phenomena which have been observed in both women and men treated with female hormones1,2. In sharp contrast there are no data on the effect of androgenic steroids on the development of arterial thrombosis, in spite of the fact that the incidence of ischaemic heart disease in human males is much greater than in the pre-menopausal females3.
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References
Astedt, B., Am. Heart J., 90, 1–3 (1975).
Sotaniemi, E. A., and Kontturi, M. J., Scand. J. Urol. Nephr., 9, 89–93 (1975).
Final Mortality Statistics, 23 (National Centre for Health Statistics, Department of Health, Education and Welfare, Washington, DC, 1971).
Hornstra, G., and Vendelmans-Starrenburg, A., Atherosclerosis, 17, 369–382 (1973).
Maekawa, T., Arai, H., and Kobayashi, N., in Platelets, Thrombosis and Inhibitors (edit. by Didisheim, P., Shimamoto, T., and Yamazaki, H.), 364–370 (Schattauer, Stuttgart and New York, 1974).
Amos, S., Odake, K., Ambrus, C. M., and Ambrus, J. L., Proc. natn. Acad. Sci. U.S.A., 62, 150–154 (1959).
Johnson, M., and Ramwell, P. W., The Physiologist, 17, 256 (1974).
Johnson, M., Ramey, E., and Ramwell, P. W., Nature, 253, 355–357 (1975).
Johnson, M., Ramey, E., and Ramwell, P. W., Fedn Proc., 34, 484 (1975).
Furman, R. H., in Menopause and Aging (edit. by Ryan, K. J., and Gibson, D. C.), 39 (DHEW Publication No (NIH) 73–319, 1971).
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UZUNOVA, A., RAMEY, E. & RAMWELL, P. Effect of testosterone, sex and age on experimentally induced arterial thrombosis. Nature 261, 712–713 (1976). https://doi.org/10.1038/261712a0
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DOI: https://doi.org/10.1038/261712a0
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