Abstract
THYROTROPIN-releasing hormone (TRH) is the tripeptide pyroglutamyl-histidyl-proline-NH2, which causes the release of prolactin and thyrotropin from the anterior pituitary gland in man and other animals1–3. Although the isolation of TRH was based on its ability to release thyrotropin, injection of TRH usually releases both prolactin and thyrotropin4,5. In spite of this knowledge, the physiological role of TRH in the control of either thyrotropin or prolactin secretion is not clear. We report here that the release and synthesis of prolactin are controlled independently by TRH in rat GH cells.
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DANNIES, P., TASJIAN, A. Release and synthesis of prolactin by rat pituitary cell strains are regulated independently by thyrotropin-releasing hormone. Nature 261, 707–710 (1976). https://doi.org/10.1038/261707a0
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DOI: https://doi.org/10.1038/261707a0
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