Abstract
MICROFILAMENTS, which are thought to be activated by Ca2+, are functionally related to the apical constriction of neural plate cells during neural tube morphogenesis. Papaverine interferes with Ca2+ flux and inhibits neurulation, disrupting microfilament structure, while ionophore A23187 which induces Ca2+ flux counteracts this inhibition restoring microfilaments and promoting formation of neural ridges and folds in 10 min. We conclude that microfilament-generated morphogenetic movement may be regulated, in part, by Ca2+ availability.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schroeder, T. E., Biol. Bull., 137, 413–414 (1969).
Spooner, B. S., and Wessels, N. K., Proc. natn. Acad. Sci. U.S.A., 66, 360–364 (1970).
Gingell, D. J., J. Embryol. exp. Morphol., 23, 583–609 (1970).
Wessels, N. K., et al. Science 171, 135–143 (1971).
Schroeder, T. E., and Strickland, D. L., Expl Cell. Res., 83, 139–142 (1974).
Imai, S., and Takeda, K., J. Physiol., Lond., 190, 155–169 (1967).
Ash, J. F., Spooner, B. S., and Wessels, N. K., Devl Biol., 33, 463–469 (1973).
Schroeder, T. E., Am. Zool., 13, 949–960 (1973).
Moran, D. J., and Rice, R. W., J. Cell Biol., 64, 172–181 (1975).
Burnside, B., Am. Zool., 13, 989–1006 (1973).
Burnside, B., Devl Biol., 26, 416–441 (1971).
Lofberg, J., Devl Biol., 36, 311–329 (1974).
Barth, L. G., and Barth, L. J., Devl Biol., 20, 236–262 (1969).
Barth, L. G., and Barth, L. J., Devl Biol., 28, 18–51 (1972).
Perry, M., J. Embryol. exp. Morphol., 33, 127–146 (1975).
Huxley, H. E., Nature 243, 445–449 (1973).
Weisenberg, R. C., Science, 177, 1104 (1972).
Moran, D. J., and Rice, R. W., J. Cell Biol., 63, 232a (1974).
Moran, D. J., and Mouradian, W. E., Devl Biol., 46, 422–429 (1975).
Wolff, D. P., Devl Biol., 40, 102–115 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MORAN, D., RICE, R. Action of papaverine and ionophore A23187 on neurulation. Nature 261, 497–499 (1976). https://doi.org/10.1038/261497a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/261497a0
This article is cited by
-
Calcium Spikes in Epithelium: study on Drosophila early embryos
Scientific Reports (2015)
-
Lipid droplets of neuroepithelial cells are a major calcium storage site during neural tube formation in chick and mouse embryos
Experientia (1992)
-
Computer modelling of neural tube defects
Acta Biotheoretica (1991)
-
Possible involvement of calmodulin in apical constriction of neuroepithelial cells and elevation of neural folds in the chick
Experientia (1985)
-
Rapid induction of morphogenetic movement in amphibian gastrulae with Ca2+ ionophores
Wilhelm Rouxs Archives of Developmental Biology (1985)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
