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Lectin-mediated attachment of glycoprotein-bearing liposomes to cells

Nature volume 261, pages 235–238 (1976)Cite this article

Abstract

LIPOSOMES have been used as vehicles for transporting drugs or enzymes into cultured cells and into tissues1–8. Before the full potential of liposome delivery systems can be realised, however, means must be found to direct the drug or enzyme bearing particles to specific sites within the body. Some modulation of the in vivo distribution of liposomes can be achieved by altering the size or charge of the vesicles9,10. More precise control of the interaction of liposomes with cells, and their distribution in vivo, may, however, be possible through the introduction of specific macromolecular entities into the liposome membrane. As a preliminary step in this direction we have incorporated a macromolecular lectin receptor into liposome membranes and have examined the lectin-mediated attachment of such liposomes to cells in vitro.

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Author notes

  1. R. L. JULIANO: Also at: Department of Medical Biophysics, University of Toronto, 500 Sherbourne Street, Toronto, Ontario.

Authors and Affiliations

  1. Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada

    R. L. JULIANO & D. STAMP

Authors
  1. R. L. JULIANO
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  2. D. STAMP
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JULIANO, R., STAMP, D. Lectin-mediated attachment of glycoprotein-bearing liposomes to cells. Nature 261, 235–238 (1976). https://doi.org/10.1038/261235a0

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  • DOI: https://doi.org/10.1038/261235a0

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