Abstract
INDUCTION of tolerance by haptens linked to non-immunogenic carriers1–5 is used widely, not only to investigate the cellular mechanism of tolerance6 but also as a new approach to the treatment of experimental immune disease7. A potentially therapeutic application of carrier-induced tolerance is the treatment of allergic diseases. In this respect, systemic hypersensitivity reactions to penicillin constitute a major cause of death due to anaphylaxis, and penicilloyl determinant is involved in approximately half of the cases8–10. We report here the suppression of reaginic antibody to the benzyl penicilloyl (BPO) determinant in un-primed as well as primed mice.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Borel, Y., Nature new Biol., 230, 180–182 (1971).
Golan, D. T., and Borel, Y., J. exp. Med., 134, 1046–1061 (1971).
Katz, D. H., Davie, J. M., Paul, W. E., and Benacerraf, B., J. exp. Med., 134, 201–213 (1971).
Hamilton, J. A., and Miller, J. F. A. P., Eur. J. Immun., 4, 261 (1974).
Moorhead, J. W., Walters, C. S., and Claman, H. N., J. exp. Med., 137, 141 (1973).
Aldo-Benson, M., and Borel, Y., J. Immun., 112, 1793–1803 (1974).
Borel, Y., Lewis, R. M., and Stollar, B. D., Science, 182, 76–78 (1973).
Levine, B. B., and Zolov, D. M., Allergy, 43, 231–244 (1969).
Adkinson, N. F., Thompson, W. L., Maddrey, W. C., and Lichtenstein, L., New Engl. J. Med., 285, 22–24 (1971).
Vickers, M. R., and Assem, A. S. K., Immunology, 26, 425–440 (1974).
Hyslop, N. E., and Milligan, R. M., Antimicrob. Agents Chemother., 5, 617–619 (1974).
Borel, Y., Golan, D. T., Kilham, L., and Borel, H., J. Immun., 116, 854 (1976).
Mota, I., Wong, D., Sadun, E. H., and Gore, R. W., Cellular and Humoral Mechanism in Anaphylaxis and Allergy, 23–26 (Karger, Basel, 1969).
Levine, B. B., and Vas, N. M., Int. Arch. Allergy, 39, 156–171 (1970).
Katz, D. H., Hamaoka, T., and Benacerraf, B., Proc. natn. Acad. Sci., 70, 2776–2780 (1973).
Katz, D. H., Stechschulte, D. T., and Benacerraf, B., J. Allergy clin. Immun., 55, 403–410 (1975).
Lee, W. Y., and Sehon, A. H., J. Immun., 114, 829–836 (1975).
Lee, W. Y., and Sehon, A. H., J. Immun., 114, 837–842 (1975).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BOREL, Y., KILHAM, L., HYSLOP, N. et al. Isologous IgG-induced tolerance to benzyl penicilloyl. Nature 261, 49–50 (1976). https://doi.org/10.1038/261049a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/261049a0
This article is cited by
-
Principles of synthesis of conjugated antigens
Pharmaceutical Chemistry Journal (1978)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
