Abstract
Mutants of yeast alcohol dehydrogenase have been produced that protect the cell against the poisonous aldehyde acrolein by increasing the NADH–NAD ratio. The altered properties include changes both in binding constants and in cooperativity. Such mutants may be useful in exploring the nature of adaptation at the molecular level.
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Wills, C. Production of yeast alcohol dehydrogenase isoenzymes by selection. Nature 261, 26–29 (1976). https://doi.org/10.1038/261026a0
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DOI: https://doi.org/10.1038/261026a0
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