Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism

Nature volume 260, pages 582–586 (1976)Cite this article

Abstract

Noradrenaline releases prostaglandins in the kidney, and in rats these augment rather than reduce vasoconstriction produced by the amine. Homogenates of kidneys of New Zealand rats inbred for hypertension exhibit lower prostaglandin inactivation by 15-hydroxydehydrogenase than controls. At the same time, augmentation of nor-adrenaline vasoconstriction by the released prostaglandin is exaggerated. This biochemical deject could be the inherited abnormality primarily responsible for the development of hypertension in these animals.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Smirk, F. H., and Hall, W. H., Nature, 183, 727–728 (1958).

    Article  ADS  Google Scholar 

  2. Simpson, F. O., et al., Clin. Sci. molec. Med., 45, 15s–21s (1973).

    Google Scholar 

  3. Malik, K. U., and McGiff, J. C., Circulation Res., 36, 599–609 (1975).

    Article  CAS  Google Scholar 

  4. Toblan, L., Fedn Proc., 33, 138–142 (1974).

    Google Scholar 

  5. Danon, A., Chang, L. C. T., Sweetman, B. J., Nies, A. S., and Oates, J. A., Biochim. biophys. Acta, 388, 71–83 (1975).

    Article  CAS  Google Scholar 

  6. Nugteren, D. H., and Hazelhof, E., Biochim. biophys. Acta, 326, 448–461 (1973).

    Article  CAS  Google Scholar 

  7. McGiff, J. C., Crowshaw, K., Terragno, N. A., and Lonigro, A. J., Nature, 227, 1255–1257 (1970).

    Article  ADS  CAS  Google Scholar 

  8. Leary, W. P., Ledingham, J. G., and Vane, J. R., Prostaglandins, 7, 425–432 (1974).

    Article  CAS  Google Scholar 

  9. Armstrong, J. M., thesis, Univ. London (1974).

  10. Needleman, P., Marshall, G. R., and Johnson, E. M., Am. J. Physiol., 227, 665–669 (1974).

    CAS  PubMed  Google Scholar 

  11. Ferreira, S. H., and Vane, J. R., Nature, 216, 868–873 (1967).

    Article  ADS  CAS  Google Scholar 

  12. Gilmore, N., Vane, J. R., and Wyllie, J. H., Nature, 218, 1135–1140 (1968).

    Article  ADS  CAS  Google Scholar 

  13. McGiff, J. C., Crowshaw, K., Terragno, N. A., Malik, K. U., and Lonigro, A. J., Clin. Sci., 42, 223–233 (1972).

    Article  CAS  Google Scholar 

  14. Vane, J. R., Nature new Biol., 231, 232–235 (1971).

    Article  CAS  Google Scholar 

  15. Aiken, J. W., and Vane, J. R., J. Pharmac. exp. Ther., 184, 678–687 (1973).

    CAS  Google Scholar 

  16. Pace-Asciak, C., and Cole, S., Experientia, 31, 143–144 (1975).

    Article  CAS  Google Scholar 

  17. Flores, A. G. A., and Sharp, G. W. G., Am. J. Physiol., 233, 1392–1397 (1972).

    Google Scholar 

  18. Blackwell, G. J., Flower, R. J., and Vane, J. R., Br. J. Pharmac., 55, 233–238 (1975).

    Article  CAS  Google Scholar 

  19. Weiss, L., Acta physiol. scand., Suppl., 409, 1–58 (1974).

    CAS  Google Scholar 

  20. Laverty, R., McGregor, D. D., and McQueen, E. G., N.Z. med. J., 67, 303–309 (1968).

    CAS  PubMed  Google Scholar 

  21. Anggård, E., Larsson, C., and Samuelsson, B., Acta physiol. scand., 81, 396–404 (1971).

    Article  Google Scholar 

  22. Pace-Asciak, C., J. biol Chem., 250, 2795–2800 (1975).

    CAS  PubMed  Google Scholar 

  23. Okamoto, K., and Aoki, K., Jap. Circ. J., 27, 282–293 (1963).

    Article  CAS  Google Scholar 

  24. McGriff, J. C., Itskovitz, H. D., and Terragno, N. A., Clin. Sci. molec. Med., 49, 125–131 (1975).

    Google Scholar 

  25. Vane, J. R., and McGiff, J. C., Circulation Res., 36 and 37 Suppl. I, 68–75 (1975).

    Article  Google Scholar 

  26. Horrobin, D. F., Manku, M. S., Karmali, R., Nassar, B. A., and Davies, P. A., Nature, 250, 425–426 (1974).

    Article  ADS  CAS  Google Scholar 

  27. Malik, K. U., and McGiff, J. C., Circulation Res., 35, 553–574 (1974).

    Article  CAS  Google Scholar 

  28. Malmsten, C., Hamberg, M., Svensson, J., and Samuelsson, B., Proc. natn. Acad. Sci. U.S.A., 72, 1446–1450 (1975).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wellcome Research Laboratories, Langley Court, Beckenham, Kent, BR3 3BS, UK

    J. M. Armstrong, G. J. Blackwell, R. J. Flower, J. C. McGiff, K. M. Mullane & J. R. Vane

Authors
  1. J. M. Armstrong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. J. Blackwell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. J. Flower
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. C. McGiff
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. M. Mullane
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. R. Vane
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Armstrong, J., Blackwell, G., Flower, R. et al. Genetic hypertension in rats is accompanied by a defect in renal prostaglandin catabolism. Nature 260, 582–586 (1976). https://doi.org/10.1038/260582a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/260582a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing