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Inhibition of reverse transcriptases of primate type C viruses by 7S immunoglobulin from patients with leukaemia

Abstract

WE have characterised1 type C virions which are released spontaneously from a diploid strain of human embryonic fibroblasts. These ‘HEL-12 virions’ have structural and biochemical properties of known RNA tumour viruses and are antigenically related to subhuman primate type C viruses. Immunological analyses have so far excluded cross reactivity between HEL-12 virions and avian (ASV), murine MuSV, or feline RNA sarcoma or leukaemia viruses.

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PROCHOWNIK, E., KIRSTEN, W. Inhibition of reverse transcriptases of primate type C viruses by 7S immunoglobulin from patients with leukaemia. Nature 260, 64–67 (1976). https://doi.org/10.1038/260064a0

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