Abstract
VITAMIN A (retinol) is a nutrient essential for vision, growth, reproduction and proper differentiation of epithelial tissue1. Some retinol is oxidised to retinoic acid (vitamin A acid) in vivo2, but if an animal is provided with retinoic acid in place of dietary retinol, it can only partially substitute for the missing retinol; vision3 and reproduction are impaired4. Sporn et al.5 have described two systems for evaluating the activity of retinol, retinoic acid, and their analogues in vitro. One measures the ability of such compounds to promote growth by determining RNA, DNA and protein levels after addition of the test compound to epidermal cell cultures derived from newborn mouse skin; the other measures ability to reverse metaplasia of the epithelial cells of trachea explanted to organ culture from vitamin A-deficient hamsters. Retinoic acid is active in both systems.
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CHYTIL, F., ONG, D. Mediation of retinoic acid-induced growth and anti-tumour activity. Nature 260, 49–51 (1976). https://doi.org/10.1038/260049a0
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DOI: https://doi.org/10.1038/260049a0
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