Abstract
THE report that T cells from patients with common variable hypogammaglobulinaemia can suppress immunoglobulin synthesis by B cells in vitro1 implies that some forms of hypogammaglobulinaemia could, at least in part, be maintained by a patient's own T cells. Blaese et al.2 described a phenomenon of “infectious agammaglobulinaemia” in line 6 chickens (USDA Regional Poultry Research Laboratory, East Lansing) which seems to represent an ideal laboratory model for the human disease. Transfer of agammaglobulinaemia with spleen cells has now also been observed consistently in strain FP and SC chickens22. The mechanism whereby recipients of cells from an agammaglobulinaemic donor are rendered agammaglobulinaemic is, however, difficult to analyse in such a long term in vivo system. Thus, further examination of the phenomenon would be greatly facilitated by a short term assay to allow better identification of the target cell.
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GREBENAU, M., LERMAN, S., PALLADINO, M. et al. Suppression of adoptive antibody responses by addition of spleen cells from agammaglobulinaemic chickens “immunised” with histocompatible bursa cells . Nature 260, 46–48 (1976). https://doi.org/10.1038/260046a0
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DOI: https://doi.org/10.1038/260046a0
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