Abstract
THROUGHOUT life, the outer segments of rod photoreceptors (ROS) are renewed continually1, a process that entails assembly of new disk membranes at the base of the ROS. Biosynthesis of the apoprotein of rhodopsin, the major membrane protein of the ROS disks, is known to occur in several stages in the inner segment2–5. Bok has found, however, that completion of the rhodopsin molecule by combination with its retinaldehyde prosthetic group does not take place until after the apoprotein has been transported to the ROS6, perhaps just before its insertion in to the membrane. The process continues unimpaired in darkness7,8, so that in these conditions a pool of 11-cis vitamin A should be readily available close to the site of synthesis.
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BRIDGES, C. 11-cis vitamin A in dark-adapted rod outer segments is a probable source of prosthetic groups for rhodopsin biosynthesis. Nature 259, 247–248 (1976). https://doi.org/10.1038/259247a0
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DOI: https://doi.org/10.1038/259247a0
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