Abstract
HYRAXES are unusual for small mammals because they have a long gestation period (7.5 months) for their size (2–3 kg) and intra-abdominal testes1,2. Hystricomorph rodents with long gestation periods relative to mature weight have a pregnancy-specific plasma protein with a high affinity for progesterone—progesterone-binding globulin (PBG). It occurs at high concentrations in the guinea pig and coypu, and evidently reduces the rate of progesterone clearance from blood3. We have found that, in the hyrax, the progesterone concentration in the corpus luteum is appreciable whereas that in plasma is low, and that erythrocytes metabolise progesterone in vitro. The results of this study are relevant to the phylogenetic affinity of the hyrax and elephant, and there is doubt about whether progesterone is the hormone of pregnancy in the elephant, since its concentration in the corpus luteum and peripheral plasma has been found to be very low4–7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Glover, T. D., and Sale, J. B., J. Zool., Lond., 156, 351–362 (1968).
Sale, J. B., J. Reprod. Fert., Suppl., 6, 249–263 (1969).
Heap, R. B., and Illingworth, D. V., Symp. zool. Soc., 34, 385–413 (1974).
Short, R. V., and Buss, I. O., J. Reprod. Fert., 9, 61–67 (1965).
Plotka, E. D., Seal, U. S., Scbobert, E. E., and Schmoller, G. C., Endocrinology, 97, 485–487 (1975).
Smith, J. G., Hanks, J., and Short, R. V., J. Reprod. Fert., 20, 111–117 (1969).
Hanks, J., and Short, R. V., J. Reprod. Fert., 29, 79–89 (1972).
Heap, R. B., Gwyn, M., Laing, J., and Walters, D. E., J. agric. Sci., Camb., 81, 151–157 (1973).
Challis, J. R. G., Heap, R. B., and Illingworth, D. V., J. Endocr., 51, 333–345 (1971).
Heap, R. B., Perry, J. S., and Challis, J. R. G., in Handbook of Physiology, Section 7, Endocrinology, 2, part 2 (edit. by Greep, R. O.), 217–260. (Am. Physiol. Soc., Washington DC, 1973).
Short, R. V., J. Endocr., 16, 415–425 (1958).
Lindner, H. R., Steroids, Suppl., 11, 133–148 (1965).
van der Molen, H. J., and Groen, D., Acta endocr., Copenh., 58, 419–444 (1968).
Nancarrow, C. D., and Seamark, R. F., Steroids, 12, 367–379 (1968).
Seamark, R. F., Nancarrow, C. D., and Gardiner, J., Steroids, 15, 589–604 (1970).
Lemon, M., J. Endocr., 55, 63–71 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HEAP, R., GOMBE, S. & SALE, J. Pregnancy in the hyrax and erythrocyte metabolism of progesterone. Nature 257, 809–811 (1975). https://doi.org/10.1038/257809a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/257809a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.