Abstract
MAREK'S disease (MD) is a common neoplastic disease of the domestic fowl caused by a herpesvirus (MDV). It is controlled in the field by vaccination with artificially attenuated strains of MDV, or more commonly with the antigenically related herpesvirus of turkeys (HVT)1. The nature of the immune prophylaxis is not clear; protective immunity may be directed against MDV, against the development of tumours, or both. One way in which vaccination may exert its effect is by influencing the spread of MDV within the body2. In contrast, infected birds may occasionally recover after showing signs of MD clinically, and in some birds MD lymphoproliferative lesions regress3, so it is likely that there is also an anti-tumour immune reaction. We have sought evidence for anti-tumour immunity in experimentally immunised birds.
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POWELL, P. Immunity to Marek's disease induced by glutaraldehyde-treated cells of Marek's disease lymphoblastoid cell lines. Nature 257, 684–685 (1975). https://doi.org/10.1038/257684a0
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DOI: https://doi.org/10.1038/257684a0
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