Abstract
THE progression of many viral infections can be affected by the administration of exogenous interferon or the production of endogenous interferon1,2, the concentration of which is greatest at the site of infection3,4. Therapy with interferon generally requires large amounts5,6 presumably to allow for diffusion to the site. Model studies of this phenomenon in vitro have usually been carried out in the non-physiological conditions of relatively low concentrations of interferon and room temperature7–9. To understand better the factors that govern the local protective action of interferon, we have done model experiments in tissue culture to define the time and concentration variables under strict simulation of body temperature by carrying out all manipulations in a 37 °C water bath.
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DIANZANI, F., BARON, S. Unexpectedly rapid action of human interferon in physiological conditions. Nature 257, 682–684 (1975). https://doi.org/10.1038/257682a0
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DOI: https://doi.org/10.1038/257682a0
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