Abstract
If human cells are subjected to large doses of ionising radiation and then fused with rodent cells, hybrid clones are obtained in which linked human genes may be segregated. By measuring the frequency with which pairs of linked genes are cotransferred after irradiation, it is possible to determine the linear order of groups of genes and to estimate the distances between them. This technique offers a new and systematic approach to the mapping problem.
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Goss, S., Harris, H. New method for mapping genes in human chromosomes. Nature 255, 680–684 (1975). https://doi.org/10.1038/255680a0
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DOI: https://doi.org/10.1038/255680a0
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