Abstract
SEVERAL enzymes are involved in the microbicidal activity of phagocytes1–3. Gluthathione peroxidase (GSHPx) deficiency has been associated with decreased microbicidal ability in leukocytes from two female patients with chronic granulomatous disease, a rare hereditary disorder4. With the discovery that the essential trace element selenium (Se) is an integral part of GSHPx, it is now possible to induce experimental GSHPx deficiency by feeding animals a Sedeficient diet5. We report here an impairment in the killing of yeast cells ingested by GSHPx-deficient leukocytes from rats depleted of Se.
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SERFASS, R., GANTHER, H. Defective microbicidal activity in glutathione peroxidase-deficient neutrophils of selenium-deficient rats. Nature 255, 640–641 (1975). https://doi.org/10.1038/255640a0
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DOI: https://doi.org/10.1038/255640a0
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