Abstract
WE recently described the isolation and characterisation of metabolites of polychlorinated biphenyls from field-collected samples, that is faeces from guillemots and seals1. In addition to the PCB metabolites—hydroxychlorobiphenyls—we unexpectedly found two compounds which after treatment with diazomethane gave mass spectra consistent with p,p′-DDE (1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene) containing a methoxy group (M=346 a.m.u.). To verify these observations rats were given p,p′-DDE (about 20 mg per animal dissolved in peanut oil) and the faeces investigated for the presence of phenolic metabolites as described previously1. This report deals with the structure of three phenolic metabolites—compounds Ia–IIIa (Fig. 1)—of p,p′-DDE excreted by the rat.
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SUNDSTRÖM, G., JANSSON, B. & JENSEN, S. Structure of phenolic metabolites of p,p′-DDE in rat, wild seal and guillemot. Nature 255, 627–628 (1975). https://doi.org/10.1038/255627a0
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DOI: https://doi.org/10.1038/255627a0
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