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Effect of concanavalin A and its derivative on the potassium compartmentation of Ehrlich ascites tumour cells

Nature volume 255, pages 556–557 (1975)Cite this article

Abstract

CONCANAVALIN A (con A) has become an interesting probe for the study of dynamic structures of the cell surface1–3, and of mechanisms of metabolic stimulation such as lymphoid cell transformation4,5, polymorphonuclear leukocyte respiration6, and of selective killing of the transformed cells7. The critical initial event in these phenomena is the binding of con A to specific receptor sites on the cell surface. One of the most important problems is to determine how interactions of surface receptors with this ligand are linked to the intracellular metabolism. We report here the effect of con A and its succinylated derivative (succinyl con A) on cell agglutination and the K+-compartmentation of Ehrlich ascites tumour cells (EATC).

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Authors and Affiliations

  1. Department of Biochemistry, Kumamoto University Medical School, Kumamoto

    MASAYASU INOUE

  2. Department of Biochemistry, Cancer Institute, Okayama University Medical School,

    KOZO UTSUMI

  3. Department of Pathology, Okayama University Medical School, Okayama, Japan

    SATIMARU SENO

Authors
  1. MASAYASU INOUE
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  2. KOZO UTSUMI
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  3. SATIMARU SENO
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INOUE, M., UTSUMI, K. & SENO, S. Effect of concanavalin A and its derivative on the potassium compartmentation of Ehrlich ascites tumour cells. Nature 255, 556–557 (1975). https://doi.org/10.1038/255556a0

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  • DOI: https://doi.org/10.1038/255556a0

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