Abstract
GENOMES of eukaryotes contain variable proportions of repeated base sequences of mostly unknown function1. It has been shown that nuclear RNA of sea urchin2 rat3 and Dictyostelium4 also contains repetitive sequence elements whereas polysomal messenger RNA (mRNA) does not. If mRNA is contained in the heterogeneous nuclear RNA these sequence homology experiments suggest a selective processing of 3′-fractions of nuclear poly(A) RNA with unique base sequences. Most mRNA fractions and individual mRNAs so far studied2,4–7 hybridise with single-copy DNA with the exception of Xenopus embryo mRNA which contains both unique and moderately repeated sequences8. Functions for the repeated base sequences in RNA are not known and could involve regulation of transcription processing or translation as well as copying of some sequences significant for DNA replication and recombination1,9. We have now used the naturally synchronous mitotic cycle of Physarum10 to investigate whether there are changes in the degree of repeated sequences in RNA transcribed in S phase and G2 phase.
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FOUQUET, H., SAUER, H. Variable redundancy in RNA transcripts isolated in S and G2 phase of the cell cycle of Physarum. Nature 255, 253–255 (1975). https://doi.org/10.1038/255253a0
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DOI: https://doi.org/10.1038/255253a0
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