Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Evidence against clustering of thymine dimers in ultraviolet-irradiated DNA

Nature volume 255, pages 245–247 (1975)Cite this article

Abstract

IRRADIATION of DNA with ultraviolet light causes chemical and physical alterations. From the chemical point of view the main effect of 254 nm UV light is the formation of pyrimidine dimers. The physical consequence of this is a destabilisation of the DNA double helix presumably by formation of small denatured regions (defects).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Shafranovskaya, N. N., Trifonov, E. N., Lazurkin, Yu. S., and Frank-Kamenetskii, M. D., Nature new Biol., 241, 58–60 (1973).

    Article  CAS  Google Scholar 

  2. Trifonov, E. N., Shafranovskaya, N. N., Frank-Kamenetskii, M. D., and Lazurkin Yu, S., Molec. Biol., 2, 887–897 (1968).

    CAS  Google Scholar 

  3. Lazurkin, Yu. S., Frank-Kamenetskii, M. D., and Trifonov, E. N., Biopolymers, 9, 1253–1306 (1970).

    Article  CAS  Google Scholar 

  4. Rahn, R. O., and Stafford, R. S., Nature, 248, 52–54 (1974).

    Article  ADS  CAS  Google Scholar 

  5. Reimer, L., Elektronenmikroskopische Untersuchungs-und Präparationsmethoden, 435 (Springer, Berlin, Heidelberg and New York, 1967).

    Book  Google Scholar 

  6. Freifelder, D., and Davison, P. F., Biophys. J., 3, 49–63 (1963).

    Article  CAS  Google Scholar 

  7. Sauerbier, W., Millette, R. L., Hackett, P. B., Jr., Biochim. biophys. Acta, 209, 368–386 (1970).

    Article  CAS  Google Scholar 

  8. Denhardt, D. T., and Sinsheimer, R. L., J. molec. Biol., 12, 674–694 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biophysics Free University, De Boelelaan 1081, Amsterdam, The Netherlands

    L. S. JONKER & JOH. BLOK

Authors
  1. L. S. JONKER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JOH. BLOK
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

JONKER, L., BLOK, J. Evidence against clustering of thymine dimers in ultraviolet-irradiated DNA. Nature 255, 245–247 (1975). https://doi.org/10.1038/255245a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/255245a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing