Abstract
ONE of the most clinically troublesome aspects of cancer is metastasis the spread of tumour cells from primary to distant multiple secondary sites1–3. Metastasis initially occurs through tissue invasion followed by transportation of tumour cells through the circulatory system lymphatics or coelomic cavities1,2. In blood-borne metastasis free tumour cells or cell aggregates are carried into various organs and tissues where they stop in the first capillary bed encountered; however most of these arrested tumour cells break loose recirculate and stop in other organs4,5. In many tumour systems the location and extent of established secondary tumour colonies are non-random suggesting that unique cell properties are important in tumour arrest and metastasis3,6. In support of this hypothesis Fidler7 was able to select from a murine B16 melanoma line variants that showed enhanced metastatic behaviour by repeated cycling of tumour cells from lung colonies to tissue culture administering the tumour cells intravenously on each cycle. We report here the organ adhesive specificity of four B16 variant cell lines selected for enhanced lung metastasis.
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NICOLSON, G., WINKELHAKE, J. Organ specificity of blood-borne tumour metastasis determined by cell adhesion?. Nature 255, 230–232 (1975). https://doi.org/10.1038/255230a0
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DOI: https://doi.org/10.1038/255230a0
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