Abstract
MUCH interest has been rekindled in the possible use of hyperthermia either alone or as an adjunct to more conventional treatments in the management of malignant disease. There are several reasons for this renewed interest: data indicate that malignant murine cells may be more sensitive to increased temperature than their normal counterparts1,2; temperatures in the range 39–43 °C sensitise cells and particularly radio-resistant hypoxic cells to X rays3–6 and to chemotherapeutic agents7–9; and humans can stand prolonged exposures to temperatures up to 43 °C provided adequate supportive precautions are taken10,11.
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KASE, K., HAHN, G. Differential heat response of normal and transformed human cells in tissue culture. Nature 255, 228–230 (1975). https://doi.org/10.1038/255228a0
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DOI: https://doi.org/10.1038/255228a0
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