Abstract
THE potential of α-chlorohydrin (3-chloro-1,2-propanediol; Fig. 1a) as an orally active reversible male antifertility agent has been demonstrated in the rat1,2, ram3 and boar4. Adverse side-effects, however, particularly in the monkey5, have precluded human trials and for this reason, elucidation of the mechanism of action6,7 of α-chlorohydrin is clearly important in order to develop less toxic yet more active antifertility analogues. Although high doses obstruct the lumen of the caput epididymis of the rat2, the initial and primary contraceptive effect seems to be directly on spermatozoa within the cauda epididymis8–11.
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MOHRI, H., SUTER, D., BROWN-WOODMAN, P. et al. Identification of the biochemical lesion produced by α-chlorohydrin in spermatozoa. Nature 255, 75–77 (1975). https://doi.org/10.1038/255075a0
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DOI: https://doi.org/10.1038/255075a0
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