Abstract
THE hypophysiotropic luteinising hormone-releasing hormone (LHRH) has a number of distinct actions on the anterior pituitary gland. In addition to stimulating the release and increased synthesis of gonadotrophins1, this peptide also has a priming or self-potentiating effect so that intermittent stimulation of the pituitary with identical doses of LHRH causes a progressively increasing series of responses of luteinising-hormone (LH) secretion. Self-potentiation by LHRH has been observed in vivo in rats2 and man3 and may play an important role in the generation of the LH surge which precedes ovulation. The effect can be obtained4 following repeated, brief exposures of the isolated, perifused rat pituitary gland to LHRH and the time course of development and decay of the potentiated state in these conditions is similar to that observed in the intact rat2. We have investigated the effects of an inhibitor of protein synthesis on this phenomenon and report here that cycloheximide suppresses the priming effect of LHRH without impairing the acute response of LH release.
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EDWARDSON, J., GILBERT, D. Sensitivity of self-potentiating effect of luteinising hormone-releasing hormone to cycloheximide. Nature 255, 71 (1975). https://doi.org/10.1038/255071a0
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DOI: https://doi.org/10.1038/255071a0
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