Abstract
A FRACTION isolated from normal human plasma1, contains a substance of low molecular weight (< 500) which shows anti-inflammatory activity in a number of animal models, including paw oedema tests in the mouse and rat1,2, adjuvant arthritis in the rat3 and Arthus reactions in the rat and rabbit4. Its activity in the carrageenin-induced paw oedema test in the rat does not involve an interference with either the release or action of chemical mediators of inflammation such as histamine, 5-hydroxytryptamine, kinins or prostaglandins5,6. The fraction is not active in inflammatory reactions in which these mediators play the more prominent role, for example, passive cutaneous anaphylaxis and the extravasation of plasma protein elicited by intradermal challenge with the mediators4, but shows marked and reproducible anti-inflammatory activity in situations in which the emigration of circulating leukocytes is a major factor, for example, Arthus reactions and the accumulation of polymorphonuclear and mononuclear cells into pleural and other inflammatory exudates7. The plasma fraction causes a reduction of up to 90% in the migration of leukocytes into the exudates found in porous inert sponges implanted subdermally in the rat7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ford-Hutchinson, A. W., Insley, M. Y., Elliott, P. N. C., Sturgess, E. A., and Smith, M. J. H., J. Pharm. Pharmac., 25, 881–886 (1973).
Smith, M. J. H., Colledge, A. J., Elliott, P. N. C., Bolam, J. P., and Ford-Hutchinson, A. W., ibid, 26, 836–837 (1974).
Elliott, P. N. C., Bolam, J. P., Ford-Hutchinson, A. W., and Smith, M. J. H., ibid, 26, 751–752 (1974).
Bolam, J. P., Ford-Hutchinson, A. W., Elliott, P. N. C., and Smith, M. J. H., ibid, 26, 660–661 (1974).
Bolam, J. P., Elliott, P. N. C., Ford-Hutchinson, A. W., and Smith, M. J. H., ibid, 26, 434–440 (1974).
Smith, M. J. H., Ford-Hutchinson, A. W., Elliott, P. N. C., and Bolam, J. P., ibid, 26, 692–698 (1974).
Ford-Hutchinson, A. W., et al., ibid, 27, 106–112 (1975).
Nelson, R. A., in The Inflammatory Process 3, second ed. (edit. by Zweifach, B. W., Grant, L., and McCluskey, R. T.), (Academic, New York, 1974).
Grant, L., ibid, 2.
Wiener, S., Lendvai, S., Rogers, B., Urivetsky, M., and Meilman, E., Am. J. Path,, 73, 807–816 (1973).
Boyden, S., J. exp. Med., 115, 453–466 (1962).
Goetzl, E. J., and Austen, K. F., J. exp. Med., 136, 1564–1580 (1972).
Stevenson, R. D., Clin. exp. Immun., 14, 417–426 (1973).
Böyum, A., Scand. J. clin. Lab. Invest. 21, suppl. 97, 77–89 (1968).
Maini, R. N., Roffe, L. M., Magrath, I. T., and Dumonde, D. C., Int. Archs Allergy appl. Immun., 45, 308–321 (1973).
Durance, R. A., Micheli, A., and Pallet, G. H., Ann. rheum. Dis., 33, 216–229 (1974).
Vogt, W., Pharmac. Rev., 26, 125–169 (1974).
Goldstein, I. R., and Weissmann, G., J. Immun, 113, 1583–1588 (1974).
Ward, P. A., in Inflammation, Mechanisms and Control (edit. by Lepow, I. H., and Ward, P. A.), (Academic, New York, 1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WALKER, J., SMITH, M., FORD-HUTCHINSON, A. et al. Mode of action of an anti-inflammatory fraction from normal human plasma. Nature 254, 444–446 (1975). https://doi.org/10.1038/254444a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/254444a0
This article is cited by
-
Synthesis, characterization, and anti-rheumatic potential of phthalazine-1,4-dione and its Cu(II) and Zn(II) complexes
Medicinal Chemistry Research (2014)
-
Anti-inflammatory drugs, prostaglandins and leucocyte migration
Agents and Actions (1976)
-
Ambivalent role of copper in inflammatory disorders
Agents and Actions (1976)
-
Platelets, prostaglandins and inflammation
Agents and Actions (1976)
-
Prostaglandins and aspirin: An alternative view
Agents and Actions (1975)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.