Abstract
LYMPHOCYTE mitogens such as phytohaemagglutinin (PHA) may induce lymphocytes to mitogenesis (DNA synthesis) and cytotoxicity (lysis of target cells). Although there is evidence that these two responses are independent of each other it remains to be determined whether different lymphocyte sub-populations are involved1,2. It has been claimed that PHA is a selective T-cell mitogen but some recent work argues against such precise specificity3. There is also evidence suggesting that PHA may induce T cells to become cytotoxic but, since non-T cells may be cytotoxic under some conditions, the situation remains to be clarified1,2,4–8.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Perlmann, P., and Holm, G., Adv. Immun., 11, 117–193 (1969).
Britton, S., Perlmann, H., and Perlmann, P., Cell. Immun., 8, 420–434 (1973).
Chess, L., MacDermott, R. P., Sondel, P. M., and Schlossman, S. F., Prog. Immun., II, 3, 125–132 (1974).
Kirchner, H., and Blaese, R. M., J. Exp. Med., 138, 812–824 (1973).
Möller, G., Sjöberg, O., and Andersson, J., Eur. J. Immun., 2, 586–592 (1972).
Wislöff, F., and Fröland, S. S., Int. Archs Allergy, 45 456–466 (1973).
Stejskal, V., Härfast, B., Holm, G., and Perlmann, P., Eur. J. Immun., 4, 126–130 (1974).
O'Toole, S., Stejskal, Y., Perlmann, P., and Karlsson, M., J. exp. Med., 139 457–466 (1968).
Perper, R. J., Zee, T. W., and Mikelson, M. M., J. Lab. clin. Med., 72, 842–848, (1968).
Papamichael, M., Holborow, E. J., Keith, H. I., and Currey, H. L. F., Lancet, ii, 64–66 (1972).
Perlmann, P., and Perlmann, H., Cell. Immun., 1, 300 (1970).
Dawkins, R. L., and Zilko, P. J., Lancet, i, 368 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DAWKINS, R., ZILKO, P. Separation of cells involved in phytohaemagglutinin-induced mitogenesis and cytotoxicity. Nature 254, 144–145 (1975). https://doi.org/10.1038/254144a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/254144a0
This article is cited by
-
Immunological effects of cancer chemotherapy in malignant melanoma
Cancer Immunology Immunotherapy (1978)
-
PHA and Endotoxin stimulation of human lymphocytes separated by albumin density gradient centrifugation
Blut (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
